Protein misfolding is usually prevented by molecular chaperons. Rarely, the chaperons are not able to prevent the misfolding as a result of which the infectous molecules called prions will form.

My question is, why does the misfolding occur like what are the reasons of misfolding and what kind of mechanism occurs? I somehow find limited information on this issue.

  • $\begingroup$ Prions only occur with specific proteins. Again please do some research before posting. $\endgroup$
    – David
    Commented May 18, 2019 at 19:08
  • $\begingroup$ Your question is very broad. You can find entire review articles (or even books) dedicated to this topic. Please check out pubmed or Google scholar. $\endgroup$
    Commented May 20, 2019 at 21:41
  • $\begingroup$ The astonishing thing is not that proteins misfold, but given the astronomical number of possible ways of folding they manage not to misfold. So you are coming at the problem with the wrong mindset. If you can access to it through a university library, try this review. $\endgroup$
    – David
    Commented May 21, 2019 at 12:30


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