I've been looking around but can't find a clear answer: are chromosomal micro-deletions passed on (hereditary) or not?


Of course. Just like any other type of mutation.

If a mutation (incl. a chromosomal microdeletion) happens in the germ line, then the mutation can be passed on.

  • $\begingroup$ another question I may add/ask: if a parent has a chromosomal micro deletion, and uniparental disomy happens, then the child will inherit the deletion as well , right? Thanks for answering $\endgroup$
    – schokakola
    Jun 14 '19 at 6:18
  • $\begingroup$ Yes, necessarily. As both chromosome are passed (uniparental disomy), the one carrying the microdeletion will necessary be passed. $\endgroup$
    – Remi.b
    Jun 14 '19 at 14:14
  • $\begingroup$ To be clear, microdeletion is the term for when a gene on one chromosome replaces its counterpart, yes? $\endgroup$
    – The Nate
    Jun 17 '19 at 21:46
  • 1
    $\begingroup$ @TheNate I think (but might be wrong) it is a term mainly used in the medical field. I think it refers to a small chromosome deletion (a few kb say) that is too small to be detected by the simple colouring methods (such as FISH or G-banding) often used in medicine. $\endgroup$
    – Remi.b
    Jun 17 '19 at 22:24
  • $\begingroup$ Thanks. I'll go start some reading, then. $\endgroup$
    – The Nate
    Jun 17 '19 at 22:31

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