I recently wondered how do dogs cope without vitamin C intake like us.
A few Wikipedia pages later, I learned that our dry-nosed ancestors lost about two-thirds of the gene responsible for vitamin C synthesis some 63 millions years ago. And then this passage:
Johnson et al. have hypothesized that the mutation of the GULOP (pseudogene that produces L-gulonolactone oxidase) so that it stopped producing GULO may have been of benefit to early primates by increasing uric acid levels and enhancing fructose effects on weight gain and fat accumulation. With a shortage of food supplies this gave mutants survival advantage.
(Wikipedia: L-gulonolactone oxidase)
I'm curious about the interaction (GULO/uric acid/fructose effects/fat storage) quoted above.