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I am looking into Vitiligo it's an autoimmune disease that results in apoptosis of melanocytes due to misfolded protein accumulation.

It also dramatically increases breast cancer rates (600 times) within one to five years from the first symptoms of Vitiligo. One function of melanocytes is to produce chemokines however I was unable to find any info on which ones.

Which chemokines are being produced by melanocytes?

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Melanocytes of vitiligo patients have strong basal expression of chemokine-receptor-3 (CXCR3) isoform B which is directly regulated by IFNγ. CXCR3B activation by CXCL10 at the surface of cultured human melanocytes induces their apoptosis. The remaining melanocytes, activated by the IFNγ production, express co-stimulatory markers which trigger T-cell proliferation and subsequent anti-melanocytic immunity.

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  • $\begingroup$ Hi Sristi, Chemokine receptor is not chemokine... I am looking not what activates melanocytes, but which chemokines they produce. $\endgroup$ – Matas Vaitkevicius Aug 8 at 8:58

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