2
$\begingroup$

I looked up the amino acid sequence of lysozyme here: http://www.biology-pages.info/L/Lysozyme.html

Then I crossed referenced that with the lysozyme sequence on UniProt: https://www.uniprot.org/uniprot/B8YK79

My question is why does the sequence on UniProt start with eighteen other amino acids before getting to the start of the sequence described in the first source?

The sequence on UniProt starts with "MRSLLILVLCFLPLAALG". I know the M comes from the start codon in the gene for the protein, but where does the rest of this come from?

$\endgroup$
4
$\begingroup$

If you scroll down through the uniprot entry you will come to a section with the heading PTM/Processing.

From this you can see that the first 18 amino acids are a signal peptide.

You can learn more about signal peptides from any good introductory textbook covering cell-biology — alternatively Khan Academy is a good source for learning the basics.

$\endgroup$

Your Answer

By clicking “Post Your Answer”, you agree to our terms of service, privacy policy and cookie policy

Not the answer you're looking for? Browse other questions tagged or ask your own question.