Is it plausible to consider increasing adipocyte size as a causal factor predicting less energy intake in humans in conditions of energy balance. It is well known that higher fat mass (FM) predicts less ad libitum energy intake in humans in controlled studies likely due to the cues sent by satiety hormones. However, independent of FM and adiposity measures, what could be the possible mechanism that adipose cell size per se can signal to reduce energy intake. Perhaps a larger adipose size means more triglycerides are stored and so in conditions of energy balance the body is "told" that energy reserves are in good shape so signals point toward "don't eat". Speculation welcomed.

  • $\begingroup$ One of the hypothesis is that there are two ways to "signal" that the body is saturating in term of triglycerides storage: adipocyte number and the size of the adipocytes. As far as I know it is not clear which one of the two happen first but both lead to more storage space. I could guess that this would have an impact on the type of signaling. $\endgroup$ – Dr. H. Lecter Sep 12 '19 at 11:36

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