Is it plausible to consider increasing adipocyte size as a causal factor predicting less energy intake in humans in conditions of energy balance. It is well known that higher fat mass (FM) predicts less ad libitum energy intake in humans in controlled studies likely due to the cues sent by satiety hormones. However, independent of FM and adiposity measures, what could be the possible mechanism that adipose cell size per se can signal to reduce energy intake. Perhaps a larger adipose size means more triglycerides are stored and so in conditions of energy balance the body is "told" that energy reserves are in good shape so signals point toward "don't eat". Speculation welcomed.