2
$\begingroup$

I've seen the plots and they don't look drastically different. Why do this?

Why use a logarithmic scale when plotting pharmacodynamics/kinetics?

$\endgroup$
  • 3
    $\begingroup$ Is there a specific type of plot you're referring to? $\endgroup$ – canadianer Sep 12 at 20:54
  • 1
    $\begingroup$ concentration time profile $\endgroup$ – user52550 Sep 12 at 21:21
  • 1
    $\begingroup$ Well, for example, plotting log concentration against time for a first order process gives a straight line with a slope equal to the negative rate constant. $\endgroup$ – canadianer Sep 12 at 22:00
  • $\begingroup$ @canadianer That should probably be an answer. $\endgroup$ – Bryan Krause Sep 12 at 22:44
2
$\begingroup$

There could be several reasons for this. You mention in the comments that your plot of interest is the concentration-time profile. As you can see, plotting the logarithm of concentration vs time yields a very different plot for a drug administered intravenously. enter image description here

The reason this is done is because the two plots yield different information. The slope of the log(C) vs t plot actually yields the elimination constant, Ke. The logarithmic plot can also be used to assess if the drug is distributed into one or more compartments. If the drug is distributed into two or more compartments, the initial slope would be different than the remainder (but this is not pictured here).

In terms of pharmacodynamics, its often useful to assess how a 10- or 100- fold increase in concentration affects the effect.

$\endgroup$

Your Answer

By clicking “Post Your Answer”, you agree to our terms of service, privacy policy and cookie policy