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I am doing a research project on the peroxisomes, and in it I referenced the enzyme catalase, which breaks down hydrogen peroxide into water and oxygen. However, the assignment asks me to specify the production location of all enzymes, and I cannot find any useful information about where the enzyme is created. I think it is created in the peroxisome itself, but am not so sure of that. Where is catalase produced?

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  • $\begingroup$ According to this source ncbi.nlm.nih.gov/books/NBK26858 , peroxisomes don't have ribosomes. Thus the source of catalase isn't the peroxisome. $\endgroup$ – Harun Sep 22 '19 at 11:37
  • $\begingroup$ Are you sure that your assignment does not ask to specify the subcellular localization of all enzymes? As @harun points out, proteins are made on the ribosome. Totally unrelated to your question, but perhaps of interest. Catalase is one of the few enzymes that is inactivated by its substrate and it has evolved an elaborate 'defense' mechanism' to counteract this: catalase contains tightly bound NADPH. $\endgroup$ – user1136 Sep 22 '19 at 13:28
  • $\begingroup$ Catalase is also a diffusion controlled enzyme with an enormous kcat (and as the Km is the ratio of the specificity constant [for catalase at the diffusion-controlled limit)] and the kcat [very high for catalase], the Km is very high, in excess of 1M !). Catalase is rarely if ever 'saturated'. $\endgroup$ – user1136 Sep 22 '19 at 13:29
  • $\begingroup$ According to this source all peroxisomal proteins are synthesized on free ribosomes in the cytosol. $\endgroup$ – Harun Sep 22 '19 at 17:39

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