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Suppose there are two proteins inhibiting a particular gene. Its not necessary that both will inhibit the gene at the same time instance right? So if one protein has already inhibited that gene before the other protein, what is left for the other protein to inhibit this gene? It has already been inhibited right? What more does the other protein inhibit?

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  • $\begingroup$ Probably the proteins are competing (like a % downregulation) to bind at the gene or they bind at different parts of the gene? it depends, do you refer to a specific example? $\endgroup$ – Alessio Oct 30 at 10:20
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    $\begingroup$ Inhibition does not necessarily need to be competitive, i.e. in the same place, i.e. the inhibitors work on different targets at the same time. Inhibition also need not be 'total', it can be partial. The inhibitors can be partial, additive or even synergistic (joint inhibition is greater than the sum inhibition of its parts). Single inhibitors can also sometimes inhibit multiple targets, so any 'extra leftover' inhibitors can work on other targets. Or work at different times in development; i.e. an inhibitor can have different targets in the embryo vs. the adult, or in tissue A vs. tissue B. $\endgroup$ – S Pr Oct 30 at 10:24
  • $\begingroup$ Can you give me a link to study more about inhibitors? These information that you gave me, would these be available from any source? $\endgroup$ – girl101 Oct 30 at 10:29
  • $\begingroup$ This is general information available in any biochemistry or molecular biology textbook. I think you could start with Wikipedia, it has pages upon pages on molecular inhibition. A good starting point would be enzyme inhibition. Though many targets or processes can be inhibited - not only singular enzymes - such as the transcription of genes, or the progression of the cell into the next phase of its cell cycle, or the polarization of cells, and so on and so forth. $\endgroup$ – S Pr Oct 30 at 14:33
  • $\begingroup$ the inhibitors work on different targets at the same time.- does this mean multiple molecule of the inhibitor is in action at this time? $\endgroup$ – girl101 Oct 31 at 6:56

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