I was reading this paper:
and became confused after this sentence:
"The ICM-derived mouse embryonic stem (ES) cells and epiblast-derived human embryonic stem cells have the full potential to differentiate to ectoderm, mesoderm, endoderm, and trophoblast."
As far as I know, the trophoblast is originated from morula cells that are totipotent, and ICM cells are pluripotent...
Moreover, are ESCs derived from the ICM of the blastocyst? Because if yes, does it mean that they can also become primitive endoderm and give rise to some extraembryonic tissues? Because as I know only epiblast (primitive ectoderm) gives rise to 3 germ layers... does it mean that ESC are derived from epiblast only or not?