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I'm working on a bioinformatics project where a lot of the biology I've had to learn from scratch. From my current understanding, a non-stop mutation alters a stop codon such that the transcription continues, and a splice site mutation alters the region between introns and exons - where the sequence may include introns, or remove part of the exons from cancer.gov. I'm inferring therefore that these could be the same mutation type.

Is this understanding correct?

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No, those kinds of mutations are quite distinct. Also, you misstate the nature of a nonstop mutation; the change of a stop codon affects termination of translation, not transcription. This is quite different from a splice-site mutation, which affects splicing, a form of mRNA processing that occurs between transcription and translation.

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  • $\begingroup$ Great thanks for clearing that up $\endgroup$ Dec 7, 2019 at 17:57

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