I've come across several studies in which scientists were investigating various questions related to neural activity by focusing on neuronal cell bodies using Calcium imaging. As this article suggests for example, cytosolic Ca concentration in the soma will significantly increase if the neuron fires. I understand the process behind this. But I'd like to find out if this somatic Ca increase has significant downstream effects inside the soma.
Could anyone shed some light on such known processes/pathways?
I've thought of one possibility based on an article that showed Calcium would upregulate mitochondrial enzymes, such as PDH and OGDC, responsible for TCA reactions. Considering that there's a coupling (source) between cytosolic and mitochondrial Ca concentrations, this could lead to a very quick increase in metabolic activity that covers up for the ATP loss related to neuron firing. However, I'm a bit skeptical about this idea. I'd think that the lack of ATP and low NADH/NAD ratio should speed up the TCA enough already and Ca might be more critical somewhere else instead.