I've come across several studies in which scientists were investigating various questions related to neural activity by focusing on neuronal cell bodies using Calcium imaging. As this article suggests for example, cytosolic Ca concentration in the soma will significantly increase if the neuron fires. I understand the process behind this. But I'd like to find out if this somatic Ca increase has significant downstream effects inside the soma.

Could anyone shed some light on such known processes/pathways?

I've thought of one possibility based on an article that showed Calcium would upregulate mitochondrial enzymes, such as PDH and OGDC, responsible for TCA reactions. Considering that there's a coupling (source) between cytosolic and mitochondrial Ca concentrations, this could lead to a very quick increase in metabolic activity that covers up for the ATP loss related to neuron firing. However, I'm a bit skeptical about this idea. I'd think that the lack of ATP and low NADH/NAD ratio should speed up the TCA enough already and Ca might be more critical somewhere else instead.

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    – tyersome
    Dec 12 '19 at 21:03
  • $\begingroup$ The attached article happens to be the exact same article that led me ask this question above. It clearly states that we can observe a Calcium increase in the soma related to action potential, but doesn't seem to discuss at all what the function of this Ca increase is. And that's what I'm asking here. I've done my research before asking. Of course, I could spend a few more days going through articles (that are often behind paywalls) and would eventually find the answer (if there is). But having to do this is exactly what I wanted to avoid by asking a clear question in a specialized community. $\endgroup$ Dec 12 '19 at 22:08
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    $\begingroup$ I think it's a good question (+1). It could be improved by a citation (e.g., to the one tyersome suggested and that you found), and also by better clarity of what exactly you are asking (I think your comment helps but comments are ephemeral). The biggest issue that you can improve is the ambiguity of the question "why": several times you ask why but why is often misinterpreted. It seems you are not interested in how the calcium gets into the cell but rather what the purpose of calcium influx is near the soma rather than at an axon terminal. If true, can you edit to make this clear? $\endgroup$
    – Bryan Krause
    Dec 12 '19 at 22:40
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    $\begingroup$ (these edits will help you get an answer that's actually what you want, otherwise someone could come and write an excellent answer about voltage gated calcium channels and then they will find they wasted their time if this wasn't what you wanted) $\endgroup$
    – Bryan Krause
    Dec 12 '19 at 22:41
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    $\begingroup$ Fair point. Thank you for your well-thought comments. I edited my question accordingly. I hope now it aligns up with the standards and readers can interpret what I'm after exactly. $\endgroup$ Dec 13 '19 at 0:00

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