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In molecular dynamics simulations of proteins, the radius of gyration is often used to assess the compactness of a protein.
When comparing two protein radius of gyration, what difference can be considered significant 1 angstrom, 5 angstroms, 10 angstroms? Significant meaning: yes it is definitely more compact or no it is definitely not more compact. I have been searching through but can't find any reference related to that.

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  • $\begingroup$ Welcome to Biology.SE! I think this is actually a statistics question in disguise — whether a difference is significant will depend on the degree of variance in the two values you are comparing! Also note that these answers will always be probabilistic rather than Boolean (yes or no) ... ——— Please also take the tour and then go through the help pages starting with How to Ask questions effectively on this site. Thanks! 😊 $\endgroup$ – tyersome Jan 16 '20 at 22:03
  • $\begingroup$ If you need an introduction to statistics, I have found starting with a relatively accessible and reliable source like Khan Academy to be very helpful. $\endgroup$ – tyersome Jan 16 '20 at 22:06
  • $\begingroup$ @tyersome The question is more about the threshold one should use to apply a statistical test. The test will tell wheater there is a significant difference or not at a given threshold (1 angstrom, 5 angstroms, 10 angstroms). I think a simple t-test is enough. But a which threshold to use is more biology-related. $\endgroup$ – BND Sep 8 '20 at 18:52

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