I'm a little confused about the wording of these two phrases and under which context the epithelial-mesenchymal transition occurs.
Is it the circulating tumor cell that releases the ctDNA so that it undergoes EMT?
ctDNA from the CTC somehow creating new instructions for the EMT phenomenon to occur?
I think there is something I am fundamentally confused about and or I am mixing several or different concepts and phenomenon together and would like to get some clarification on this. Thanks.
EDIT: So this is my new hypothesis / thinking..
So when EMT occurs, CTCs are more likely to develop in the context of cancer, and so when CTCs circulates throughout the blood stream CTCs may be apoptosed of necrosed as a by-product thus leaving ctDNA in the bloodstream and or possibly through out the body.
Is that a correct explanation to my confusion?