According to Wikipedia, the median size of a protein-coding gene is 26,288 bp which makes it possible (from statistical considerations) that the nucleotides C, G, A, T appear in roughly equal amounts in one strand. But maybe this is wrong so I want to ask:
Are there and which specific protein-coding genes have a significant inbalance of amounts of C, G, A, T in one strand?
Related to this is the question if there are larger proteins (containing up to 27,000 amino acids as the titins do) with a significant inbalance of amounts of the 20 different amino acids?
Might it be the case that from an inbalance of the gene an inbalance of the protein may follow?