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Full disclosure: I am not a biologist and this is more of a general question about understanding antibiotic resistance of bacteria.

We are always told that careless antibiotics use is the cause of new more resistant bacteria, which can obviously devastate huge societies and even have global impact. At the same time from my knowledge it seems that bacteria mutates in a purely random fashion.

So, thinking about this concept probabilistically, the virus mutating and antibiotic consumption seem to be completely disjoint events such as:

$$P(M|A) = \dfrac{P(M \cap A)}{P(A)} =\dfrac{P(M) P(A)}{P(A)} = P(M)$$

Where $M$ is the event that the bacteria mutates and $A$ is the event of taking an antibiotic. I couldn't find any research online as to how $P(M)$ is actually modelled or what probability distribution it even roughly follows, but intuitively it would depend on time as the longer the bacteria spends inside the host the higher the probability of mutation would be. So from this train of thought it would seem that taking antibiotics would actually be a good idea as to eradicate the bacteria quicker and give it less chance to mutate down the line.

I am obviously not trying to discredit hundreds of years of research and understand that there must be a gap in my thinking somewhere. My question is, why are we told that antibiotics cause antibiotic resistance even though the mutations are described as 'random'?

(ELI5 explanations are preferred as I said I don't come from a biology background)

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  • $\begingroup$ Welcome to Biology.SE! Please take the tour and then go through the help pages starting with How to Ask questions effectively on this site and edit your question accordingly. In particular, you are ignoring the effects of selection, which suggests to me that you would benefit from this introduction to evolutionary theory from UC Berkeley. ——— We also encourage you to do some research on your own and then, informed by what you have learned, ask any questions you still have (ideally with references to reliable sources). Thanks! 😊 $\endgroup$ – tyersome Mar 14 at 18:10
  • $\begingroup$ I have found that when learning about a new area starting with a relatively accessible and reliable source like Khan Academy is very helpful. Wikipedia is also generally a good starting point and you can then check their references. Online platforms called MOOCs offer free (or very low cost) courses on a wide variety of subjects — two I am familiar with are Coursera and edX. Finally, textbooks with a good level of detail are also freely available online e.g. from NCBI. $\endgroup$ – tyersome Mar 14 at 18:12
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    $\begingroup$ Presence of antibiotic does not significantly affect mutation, but rather affects selection of variants. You may find this Khan Academy page helpful. $\endgroup$ – mgkrebbs Mar 14 at 18:34
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    $\begingroup$ Mutations are random. Selection of mutants (with use or overuse of antibiotics) is not random. $\endgroup$ – Alex Reynolds Mar 15 at 5:07
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There are many models for mutation accumulation (Liò and Goldman, 1998). The simplest model (Jukes and Cantor, 1969) assumes mutations to be a Poisson process. With a given mutation rate, the number of mutations accumulated will follow the Poisson distribution.

This basic model has been extended to include non-uniform mutation rate across the genome and different rates for different kinds of mutations. You can check out the link and the works it cites to have a better idea.

However, the answer to your question does not pertain to how mutations happen. Although there is some evidence that some antibiotic treatment can actually increase mutation rate (Long et al, 2016; Meouche and Dunlop, 2017, Windels et al., 2019), the main principle pertains to selection and not actually the mutations. Improper antibiotic treatment can lead to some cells with moderate resistance to survive, which in turn can evolve strong resistance. Here, we assume that the infecting bacterial pool already has enough variation (or develops during infection) some little resistance. Moreover, there is another phenomenon called persistence (ability to survive antibiotic, Brauner et al., 2016). Windels et al (2019) report that persistence can increase resistance.

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