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Can one be immune to the new coronavirus?

Another question is what is the exact definition of "being immune". Does it mean that even when the virus enters my system, it cannot multiply?

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It is hypothesized that exposure to and recovery from SARS-CoV-2 (as with other coronaviruses in humans) would generally result in short-term immunity to this strain, but we do not yet have data on this:

However, according to Dr Stephen Gluckman, an infectious diseases physician at Penn Medicine and the medical director of Penn Global Medicine, who spoke to the outlet, it seems likely that having the disease once results in immunity in most individuals - as is seen with other coronaviruses.

“Coronaviruses aren’t new, they’ve been around for a long, long time and many species - not just humans - get them,” he explained. “So we know a fair amount about coronaviruses in general. For the most part, the feeling is once you’ve had a specific coronavirus, you are immune. We don’t have enough data to say that with this coronavirus, but it is likely.”

This means that people who initially recovered are more likely to relapse rather than get reinfected with the virus.

According to one study, people with mild infections can test positive for the virus by throat swabs “for days and even weeks after their illness”.

But, that doesn’t mean it isn’t possible to contract the disease again, especially in those who are immunocompromised.

“The immune response to Covid-19 is not yet understood,” the Centers for Disease Control and Prevention (CDC) explains. “Patients with MERS-CoV infection are unlikely to be reinfected shortly after they recover, but it is not yet known whether similar immune protection will be observed for patients with Covid-19.”

It is also hypothesized (in humans) that previous exposure to coronaviruses may enable immunity to certain other highly related strains:

These data indicate that challenge immunity to coronaviruses is strong, but highly virus strain-specific.

But these are all examples of adaptive immunity - not innate.

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No, you cannot be immune to the virus, if you haven't been in contact with it before. You are also not immune to the influenza viruses (flu), you just happened to not contract any of them.

Simply speaking, being immune means that your immune system knows the specific virus and can disarm it effectively. But the immune system has to learn to recognize and how to fight a pathogen first. That's the adaptive immune response. It is build once you encounter the virus for the first time, but can also be activated by a vaccine. Having immunity enables your body to fight off the virus, before it can harm you or spread further.

How sick you get from a pathogen the first time around depends on how fast or strong your immune system can build immunity and on your innate immune response. None of this works perfectly. Even with immunity you can still get sick.

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  • $\begingroup$ In other words, "Yes, you can be immune to the virus, but only if you have been in contact with it, and some time has passed." Then, you are likely to develop immunity. $\endgroup$ – Matthew Elvey Apr 22 at 21:11
  • $\begingroup$ (..or received vaccine against it.) If you've never had the flu, it doesn't mean you are immune to the influenza viruses (flu), you probably just happened to not contract any of them. But throughout the tree of life, some parts of the tree, including subspecies, do not suffer from certain infectious diseases that other parts do. -Good edits? $\endgroup$ – Matthew Elvey Apr 22 at 21:22
  • $\begingroup$ The question was worded differently before people edited it. It was about having some "natural" immunity without exposure, because they also never got the flu.. I just wanted to help a worried person. The reality is more complicated and some data now suggests that there is actually the possibility of a "cross-immunity" from our other coronaviruses. $\endgroup$ – Frieke Apr 24 at 17:19
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The CCR5-Δ32 mutation (2 deletions) which interferes with HIV might offer "immunity" to the virus causing the pandemic. -- This was the mechanism the experimental CCR5 antagonist Leronlimab (IgG4 mAb) may have accomplished with Covid-19 for several patients.

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