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Hello and thanks for taking the time to read my post.

I know that naive T-Cells (T0) can be induced to become mature T-Helper cells (TH1 or TH2) by induction with either IL2 or IL4.

IL2+ TH0 -> TH1 Humoral (antibody-mediated)
IL4+ TH0 -> TH2 Cell Mediated response

But what I would like to know is the causal chain that creates the IL2 and IL4 cytokines.

The reason I ask is because one clinician has reported that Azythromycin(an anti biotic) is useful in treating COVID-19(a virus) disease and was wondering if the immune system might become confused about whether should develop a TH1 or TH2 response.

If you can provide me with any help I would greatly appreciate it

Thanks in Advance Michael Mckeon

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