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I keep coming across the term "polybasic cleavage site" which is implicated in increasing the virulence of many viruses, but I'm struggling to find a definition. Is it just a sequence of amino acids where more than one has a basic side chain? I'd also love to know why it is so important to the function of a virus.

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    $\begingroup$ Welcome to SE Biology. Please finish the Tour and read the Help on asking questions here. In particular note that you are expected to demonstrate that you have done some research to try to answer the question yourself. Searching for "polybasic cleavage site" brings up several relevant papers immediately. You should look at them and then if there are points you don't understand you can revise your question to highlight them. But you cannot expect us to do all the work for you. $\endgroup$ – David Mar 25 at 11:53
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    $\begingroup$ @Will I think David is indeed trying to be helpful - questions are much more clear if you can describe what you've found in your own searching and highlight where you are having trouble understanding - that will help you get an answer here. $\endgroup$ – Bryan Krause Apr 23 at 15:07

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