I was reading Schoeman, 2019 which describes possibilities for live attenuated vaccines for SARS. For example, the complete deletion of the envelope (E) protein is said to attenuate the virus. Several drugs have been proposed for use against SARS-CoV-2 as E-protein inhibitors. Alam, 2020 preprint This raises the question of whether you could make a simple delta E mutant of the virus, comparable to one which might arise by random mutation, and expose people to it in the manner of cowpox. Such an approach might be used as by a society with widespread infection and (apparently) very little biomedical infrastructure. But have any experiments of this type been done?

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    $\begingroup$ SE Biology is concerned with the mechanisms of biological processes, and questions are generally answered by people with biological rather than medical expertise. Although I understand your concern about the coronavirus outbreak, your question is not about the biology but suggestions for combating the disease. Such questions are off-topic here, although may possibly be suitable for SE Medical Sciences. You may also consult more appropriate reputable sources for such information listed here. $\endgroup$ – David Mar 24 at 21:33

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