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There has been some electron micrograph of SARS-COV-2 published; but are there any fluorescent/ confocal-fluorescent image of them? or is it possible to do them? I know that viruses are usually much smaller than capacity of light microscope but I think by using any immunofluorescent probe or FISH technique it is possible to visualise the locations occurance of the virus in cell or tissue. At least one website says it is possible to visualise viral infections using fluorescence techniques.

Now is there any such image for SARS-COV-2, and is it possible to take?

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    $\begingroup$ I'm voting to close this question as off-topic because asking for an image is not posing a biological problem. $\endgroup$ – David Mar 26 at 21:34
  • $\begingroup$ should i delete the question? $\endgroup$ – Always Confused Mar 27 at 5:35
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    $\begingroup$ It could be reformulated as a biological question: is it possible to visualize viral infections and what type of assays are routinely used? $\endgroup$ – Dr. H. Lecter Mar 27 at 7:17
  • $\begingroup$ Thank you I will do such change in language; still the question remains the same. $\endgroup$ – Always Confused Mar 27 at 7:19
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If you have an antibody against the viral proteins you can do an immuno staining followed by fluorescence imaging. For this type of technique you would need a very specific antibody. I am not aware that this exist at the moment and I don't think anyone had the time to do it for immunostaining purposes.

For FISH it would depend on the genomic nature of the virus (ssRNA, ssDNA, dsRNA, dsDNA), again you would need specific probes to capture it. Again specific is key.

EDIT 01.04.2020: This group says they have found specific antibodies https://www.centivax.com/covid19

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  • $\begingroup$ Okay then its not available yet. No, I have not facilities to work with virus. $\endgroup$ – Always Confused Mar 27 at 5:33
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    $\begingroup$ As far as I know it has not been done but who knows things are going extremely fast these days it is hard to keep track of all preprints and publications. $\endgroup$ – Dr. H. Lecter Mar 27 at 7:18

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