Yes & perhaps (or probably?) no, depending on what you define as significant changes.
Less than 10,000 years ago everyone in the british isles & the rest of europe were dark skinned so the answer if (unlike me) you consider the change in skin color a significant change is obviously a resounding yes.
Here's what English people looked like 10,000 years ago
Darker skinned than you were expecting perhaps.
If as suggested in this article white skin arrived in Europe around 5,000 years ago that only leaves 2,000 years before early Greek & Roman art we have available which shows it as ubiquitous, so it perhaps took only 2,000 years or so (maybe less) to become dominant in europe, that's fast.
Using 20 years as the measure of a generation that's only 100 generations, so, very fast.
Timeline of human prehistory
The first reconstruction in the link below is a reconstruction of a Neanderthal woman found in a cave in Gibraltar. She died at least 30,000 years ago.
Here she is, the skin tone may not be accurate but we do know from gene's recovered from Neanderthal remains that they were relatively light skinned.
Personally I don't consider her appearance to be significantly different from modern humans.
29 Reconstructed Faces Of Ancient People
So my answer based on what I consider significant changes would be no.
But for you or others the answer may well be yes.
And of course a mutation for a new eye colour could appear at any time in one individual & spread like wildfire practically overnight just because we think it's unusual & 'cool' (aka sexual selection) so if eye color ticks your boxes it's a very definite yes.