Is there any known pharmaceutical or chemical that could cause infertility in humans in a single dose with few or no other effects?

The context is that a number of claims are circulating about vaccination being a "cover" for a plot to render males and/or females infertile. I claimed that it is unlikely that there is a known way to make a person infertile with a single dose of a chemical without significant side effects. However I couldn't find a source.

I'm asking as I believe it is important to have scientifically accurate responses to rumors and the like, even if they are outlandish.

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    $\begingroup$ People believing this sort of thing usually aren't that convinced by facts. $\endgroup$ – Bryan Krause Apr 21 at 16:25
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    $\begingroup$ @BryanKrause, True, but not-yet-believers may be dissuaded from adopting the belief if contradicting facts are shown in rebuttal to the assertion. $\endgroup$ – mgkrebbs Apr 21 at 17:00
  • $\begingroup$ @mgkrebbs Sure, but, given: xkcd.com/808 this is a pretty insane claim. If there were some easy way to infertility with just a pill with no side effects we wouldn't be bothering with vasectomies, tubal ligation, etc. It's a losing battle to argue against things that don't have a basis: the burden of proof has to be on the claim not on the skeptics. $\endgroup$ – Bryan Krause Apr 21 at 17:07
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    $\begingroup$ It's hard to understand why, if such a chemical existed and was available at a price cheap enough to be used in mass vaccinations, it would not be available commercially as a less expensive alternative to vasectomy or tubal ligation. $\endgroup$ – jamesqf Apr 22 at 4:06
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    $\begingroup$ Absence of evidence... years or reading science publications I haven't heard of any. If there was a single dose infertility drug with few side effects this sure would be big, big news. Getting the influential people onside before vaccination would be good, including vaccinating oneself. $\endgroup$ – Polypipe Wrangler Apr 24 at 10:17

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