I've noticed in various COVID-19 lateral flow assays, they seem to target different antibodies (S1, S2, NP). What are the benefits or downsides of choosing different antibodies? I know that some have a higher chance of cross-reactivity, but why wouldn't all tests just use the ones with the lowest cross-reactivity?

  • $\begingroup$ I think you're confused by polyclonal tests nature.com/articles/d41587-020-00010-2 $\endgroup$ – Fizz Apr 24 at 21:22
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    $\begingroup$ I've used multiple assays. Some only respond positive to N Mab others respond positive to S1 Mab. $\endgroup$ – Sargun Dhillon Apr 24 at 23:26

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