1
$\begingroup$

I'm looking for a very small protease to base an engineered protein on. I did a search for "peptides with protease activity" but all the results seem to be as peptides to be used as protease substrates (eg in assays); I couldn't find any catalytic peptides.

What is the smallest protease or domain which has independent proteolytic activity? (Ideally looking for something very short, a dozen aminoacids)

$\endgroup$
1
$\begingroup$

60 residues is the smallest I could find, ref below.

https://jbiomedsci.biomedcentral.com/articles/10.1186/1423-0127-19-54

$\endgroup$
1
  • $\begingroup$ feel free to edit answer for style $\endgroup$ – Polypipe Wrangler Apr 29 '20 at 12:12

Your Answer

By clicking “Post Your Answer”, you agree to our terms of service, privacy policy and cookie policy

Not the answer you're looking for? Browse other questions tagged or ask your own question.