I know that plasmids can be present in a coiled form, which keeps the DNA strands together when they degenerate, by forming catenases.

I was wondering, however, whether it has been documented to naturally happen or if anybody has ever successfully created a Möbius-strip plasmid. Technically, such a structure could readily form from a single circular strand of DNA, but the literature, as far as I have searched, has remained silent.

  • $\begingroup$ Wouldn’t any covalently closer circular DNA with an odd twist be a Mobius strip? $\endgroup$ – canadianer May 23 '20 at 0:37
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    $\begingroup$ Related to your question, this paper reports Möbius strips created from multiple strands of DNA. $\endgroup$ – canadianer May 23 '20 at 0:38
  • $\begingroup$ @canadianer you can make this into an answer, since it answers my question. $\endgroup$ – TheChymera May 25 '20 at 21:53

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