I'm wondering what makes cells to divide (and stop) in such a way that they make our hands the shape that our hands are...

  • 1
    $\begingroup$ with hands, there is cell division initially to give rise to a palm bud (fingers not separate). Subsequently, the cells between the fingers (digits) die by apoptosis to give hand its shape. $\endgroup$
    Jul 26, 2013 at 2:24
  • $\begingroup$ That is exactly what is studied in developmental biology, which is a huge field of research. $\endgroup$
    – Bitwise
    Jul 26, 2013 at 15:46

1 Answer 1


Hands are complicated and the genetic machinery behind their shape doubly so.

It's easier to figure out worm segments first, and then work up from there. An egg has head/tail information encoded in it even before fertilization: see here

You can imagine the first or second cell division would give a 'head' cell with higher concentration of head polarity transcription factors. These transcription factors switch on other regulatory genes, and the complexity works upwards from there. For more information about how worms and other segmented animals work out what goes where see Hox genes. The sad truth is that most of how this is done is unknown or not well understood.


You must log in to answer this question.

Not the answer you're looking for? Browse other questions tagged .