So mutations in CF are classified by the severity of the impact on the production of the CFTR.

But an individual may have two different CFTR mutations.

I assume that the least severe mutation of the two is the most relevant to the phenotype. e.g It is more favourable to have a class I and class II mutation that to have 2 class I mutation.

However, I cannot find any references to support this or explain the molecular interaction between classes. Additionally, I fear that it may be more complex than this.

The purpose for knowing this is I want to control for CFTR class in regression analysis but I am removing individuals on ivacaftor or similar so I am talking about the effect purely at the baseline biological level rather than differential access to potentiator therapies.


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