As an example continuous high blood level of GnRH in humans causes a suppression of LH and FSH. This is due to the fact that increased GnRH downregulates GnRH-Receptors . My question is how this is done and why? What are the probable molecular mechanisms underlying this effect?

Kumar P, Sharma A. Gonadotropin-releasing hormone analogs: Understanding advantages and limitations. J Hum Reprod Sci. 2014;7(3):170-174. doi:10.4103/0974-1208.142476 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4229791/

  • $\begingroup$ Hi A.N. Ψ, Could you provide more resources on continuous high blood level of GnRH in humans causes a suppression of LH and FSH? Or on the fact that increased GnRH downregulates GnRH-Receptors? $\endgroup$ – Andrew Aug 4 at 22:23
  • $\begingroup$ Go through the paper. I have added it to the Question $\endgroup$ – A.N. Ψ Aug 5 at 16:23

Gonadotropins are hormones synthesized and released by the anterior pituitary gland, which act on the testes and ovaries to increase the production of sex hormones and stimulate production of either sperm or ova.

The hypothalamus contains Gonadotropin-releasing hormone (GnRH). Intermittent released of GnRH is responsible for the biosynthesis and secretion of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary gland.

LH stimulates interstitial cells to release testosterone, which triggers spermatogenesis. The rising level of testosterone exerts negative feedback control on the hypothalamus and pituitary glands.

GnRH has been shown here in a negative feedback loop

This feedback loop has great interplay with the number receptor levels as you suggest.

(From a quick search) I found one paper (behind a paywall) that states the following information when studying rats:

We observed an acute reduction of both GnRH and GnRH-R mRNAs 24 h after the injection [of GnRH agonist (triptorelin)] (about 38% of control).

Transcription does not equal translation, but it seems that acute increased levels of GnRH cause a reduction and mRNA of GnRH and GnRH-R and therefore potential reduction (down-regulation) of protein levels of GnRH-R.

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