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Some RNA viruses contain negative-sense RNA. Then they use this negative-sense RNA to make positive-sense RNA that is then translated into protein.

My question is what prevents the translational machinery of the cell translating the negative strand into protein? Is there some signal that indicates that this is a negative strand?

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  • $\begingroup$ I have removed the anthropomorphic expressions from your question, which implicitly assumes some sort of preventive mechanism is involved. Try looking at the other side of the coin. Have you read about translation in a standard text like Berg et al. and about virus translation, e.g. in this Wikipedia article, although this may not be typical of negative strand viruses? $\endgroup$ – David Aug 8 '20 at 14:29

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