T-cell co-stimulatory and co-inhibitory molecules (collectively named co-signaling molecules) play a crucial role in regulating T-cell activation, subset differentiation, effector function and survival. Following recognition of cognate peptide-MHC complexes on antigen-presenting cells by the T-cell receptor, co-signaling receptors co-localize with T-cell receptors at the immune synapse, where they synergize with TCR signaling to promote or inhibit T-cell activation and function.
I'm not sure I understand the second sentence. The language is a little confusing to me. Does it mean that after a TCR binds to a peptide-MHC complex, other TCRs present on the cell gather around that TCR? Does it mean that one TCR can bind more than one peptide-MHC complex (which, as far as I understand, isn't true)?
Here's my paraphrase of this sentence:
Following recognition of a cognate peptide-MHC complex on an antigen-presenting cell by a T-cell receptor, co-signaling receptors co-localize with (other) T-cell receptors at the immune synapse, where they synergize with TCR signaling to promote or inhibit T-cell activation and function.
Is it correct?
