'Both X-chromosomes in a female have an equal chance of becomes a Barr body in each cell.' Every source I can find on Barr bodies claims this and I can think of no reason for why it may be wrong. What I want to know is if anyone has empirically tested this. Has anyone ever taken a model organism, measured the distribution of Barr bodies, and calculated exactly how far the result is from the 1:1 ratio that the theory predicts? Has anyone ever tested the Null Hypothesis of this statement, or has it just been accepted based on the theory alone?

  • $\begingroup$ Generally in science, accepted theories are not simply based on a presumption of accuracy just because it sounds right. While I don't have the citations you're looking for (this would be a good place to start looking), I'm certain it's based on strong empirical evidence, not guessing. $\endgroup$ – MattDMo Aug 26 '20 at 11:49
  • $\begingroup$ That is why I asked my question. Considering how wide-spread this claim is, there should be empirical evidence, but as far as I can tell there is none. $\endgroup$ – E Tam Aug 28 '20 at 2:03
  • $\begingroup$ Did you start looking through the PubMed search I linked to? You can reverse-sort it by date published and start looking at the oldest papers first, as they're the ones most likely to have direct citations of the original work. $\endgroup$ – MattDMo Aug 28 '20 at 12:36

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