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A fracture of a bone containing bone marrow with B-cells not yet taught to not recognize self-antigen, if the bone is fractured, can those cells get released and cause problems?

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  • $\begingroup$ Most likely not, because immature cells require other signals from the marrow to survive, so "spilled" cells likely wouldn't last long. $\endgroup$
    – MattDMo
    Aug 27 '20 at 0:18
  • $\begingroup$ Thanks good answer, sounds evolutionarilly probable. $\endgroup$
    – Craig
    Aug 27 '20 at 13:17

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