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I have looked at the literature and mostly scientist discuss about how a metastatic lesion is formed. But what I am interested to learn is how does a new metastatic lesion develop when there is already several metastatic lesion already present at baseline.

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    $\begingroup$ Welcome to Biology.SE! Please edit your question and add details regarding what you already know about the subject and where specifically you're having problems understanding it. Do you know that tumor "behavior" changes during this time? My understanding is that once a tumor acquires the genetic changes required to undergo metastasis, that's it - it begins metastasizing and continues to do so. Of course, the genetic instability originally present in the tumor is still there, so I would assume mutations continue to accumulate, but they don't really effect metastasis itself. $\endgroup$ – MattDMo Sep 5 at 22:21

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