I'm looking for an enzyme that does not function as part of a complex in its active state. Preferably it also is not part of a kinase or other kind of activating cascade as well though I would appreciate any and all names that are not part of a complex in its active state. Also would be better if it does not require post translational modifications. Of course, pre translational modifications/ interactions at rna or dna level are all good. In eukaryotic genome but bonus points for human genome! Thanks!!

  • $\begingroup$ Ribozymes may answer your conundrum here. $\endgroup$
    – Andrew
    Sep 9, 2020 at 23:57
  • $\begingroup$ Ribozymes are made of 2 subunits though. I'm basically wondering if there is a protein with no quaternary structure and maybe even those little things I mentioned above. $\endgroup$ Sep 10, 2020 at 0:00
  • 2
    $\begingroup$ This seems like a XY problem $\endgroup$
    – Bryan Krause
    Sep 10, 2020 at 1:35
  • $\begingroup$ I'm not really sure how else to phrase unfortunately. But that's a good thing to learn about! Feel free to edit or advise and I'll comply! $\endgroup$ Sep 10, 2020 at 3:00
  • 2
    $\begingroup$ I can't really suggest an edit because I have no idea what problem you are trying to solve, and that's kind of the problem with XY questions. What is your goal? $\endgroup$
    – Bryan Krause
    Sep 10, 2020 at 3:29

1 Answer 1



Chosen because the esterase seems like a low energy reaction so it wouldn't need energetic co-factors.


Not sure if I should do a new answer or not.

  • $\begingroup$ Yeah. The Zn is a cofactor so technically doesn't add to the quaternary structure. I'll keep the question open in case someone identifies a completely isolated enzyme. $\endgroup$ Sep 10, 2020 at 3:02
  • $\begingroup$ @SarthakGarg , i have changed my answer. $\endgroup$ Sep 10, 2020 at 4:37

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