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For presynaptic inhibition, I am aware of these:

  1. Ca²+ influx (into the presynaptic nerve terminal) is decreased. And this in turn reduces the probability of releasing synaptic vesicles from the presynaptic neuron.

  2. The influx of Ca²+ is under the influence of voltage-gated Ca²+ channels.

My questions:

  1. What inhibitor(s) can be involved in this inhibition?

  2. What is the ionic basis of this inhibition? (By this, I want to know how the movement of ions affects the voltage-gated Ca²+ channels)

  3. Does the reaction cascade intitiated by the inhibitor in any way affect the amplitude of the AP generated upstream when it reaches the presynaptic nerve terminal?

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