For presynaptic inhibition, I am aware of these:

  1. Ca²+ influx (into the presynaptic nerve terminal) is decreased. And this in turn reduces the probability of releasing synaptic vesicles from the presynaptic neuron.

  2. The influx of Ca²+ is under the influence of voltage-gated Ca²+ channels.

My questions:

  1. What inhibitor(s) can be involved in this inhibition?

  2. What is the ionic basis of this inhibition? (By this, I want to know how the movement of ions affects the voltage-gated Ca²+ channels)

  3. Does the reaction cascade intitiated by the inhibitor in any way affect the amplitude of the AP generated upstream when it reaches the presynaptic nerve terminal?


Your Answer

By clicking “Post Your Answer”, you agree to our terms of service, privacy policy and cookie policy

Browse other questions tagged or ask your own question.