0
$\begingroup$

I guess not, but it was discovered in 2000 so I don't know if we know enough about it. Are there people without ACE2 (angiotensin converting enzyme 2)?

It seems mice can survive, but that's not a proof on humans: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4829150/

Improve this question
$\endgroup$

1 Answer 1

Reset to default
1
$\begingroup$

No obviously inactivating variants are found in this gene, which provides at least negative data (humans generally seem to have at least somewhat functional ACE2). Exome sequencing across >200K humans has found a series of variants, mostly low-frequency, in the population.

Some of these variants may affect gene function, but it is not clear how, and none of them are obviously complete loss of function variants (e.g. nonsense mutations).

A more complete analysis of the data, including e.g. CNVs, might be necessary to fully address this question.

Improve this answer
$\endgroup$

You must log in to answer this question.

Not the answer you're looking for? Browse other questions tagged .