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I have to study and implement some evolutionary statistics for P.falciparum. In your opinion and by your experience, which organism should I consider in order to take the orthologs to implement this study?In general, If I wanted to extend this study to P.knowlesi, P.vivax and in general to all the parasites evolutionary related to the asian monkey plasmodia, which organism you suggest me to consider as a template? I thought about P.berghei but, since I have to consider also the Vinckeia parasites (mouse plasmodia) is there a good organism, out of the plasmodium genus, that could come in handy serving as a reference point for all these species?

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  • $\begingroup$ Is there a reason to not do all of them, if you are only doing computational analysis ("evolutionary statistics")? The meaningfulness of the work will increase significantly with each additional organism included. $\endgroup$ Commented Oct 6, 2020 at 19:56
  • $\begingroup$ Yes the analysis is set to take in consideration the whole set of the organisms. I have only to find a good protozoan to take the orthologs. In human M. musculus is good enough, but for plasmodia?I though about some haemosporidia. What can you suggest me? $\endgroup$ Commented Oct 6, 2020 at 22:12
  • $\begingroup$ i would suggest taking orthologs from as many species as possible (ideally 10+ minimum) and using their phylogeny to combine information. estimates will only get better with more information. $\endgroup$ Commented Oct 7, 2020 at 3:58
  • $\begingroup$ Thank you for your precious suggestion $\endgroup$ Commented Oct 7, 2020 at 13:03

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