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Excluding the hypersensitive reactions which are individual specific, how is food we consume considered safe by the immune system?

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Actually for few food items we do develop some sort of immunity. Let me give an example—

Suppose in an individual's RBC membrane, there's a specific ABO antigen (let's say the subject has "A" blood group). Now in that individual, how do you think anti B antibodies will be formed?

It will essentially be due to some food intake and subsequent exposure to 'B Antigen'. Hence we usually tend to say that 'blood group—A' has anti-B antibody.

This article might be helpful (See the section: Basic Biochemistry$>$ABO Phenotype--4th paragraph)

https://www.ncbi.nlm.nih.gov/books/NBK2267/

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    $\begingroup$ Can you link to some literature that shows we are exposed to ABO antigens through food? $\endgroup$
    – MattDMo
    Oct 8, 2020 at 19:04
  • $\begingroup$ Yes, sure. I have added an article. $\endgroup$ Oct 9, 2020 at 5:17
  • $\begingroup$ That's interesting, I never knew that before. Or, if I was taught it once I forgot :) $\endgroup$
    – MattDMo
    Oct 9, 2020 at 14:24

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