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I searched about it and I just found that DNA polymerase can break this bond between the nucleotides of the new strand. (Exonuclease activity)

Is it possible that phosphodiesterase bond in the original DNA strand break during endonuclease acitivy in replication?

I'm sorry for grammatical mistakes, my English is not good.

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  • $\begingroup$ Welcome to Biology.SE! Please take the tour and then go through the help pages starting with How to Ask questions effectively on this site. In general, we expect you to do some research on your own and then, informed by what you have learned, ask any questions you still have (ideally with references to reliable sources). In particular, I have never heard of (and cannot find references to) a "primitive strand" — this suggest you lack essential background knowledge. I encourage you to master the background and standard terminology using the suggestions below. Thanks! 😊 $\endgroup$ – tyersome Oct 17 at 17:53
  • $\begingroup$ I have found that when learning about a new area starting with a relatively accessible and reliable source like Khan Academy is very helpful. Wikipedia is also generally a good starting point and you can then check their references. Online platforms called MOOCs offer free (or very low cost) courses on a wide variety of subjects — two I am familiar with are Coursera and edX. Finally, textbooks with a good level of detail are also freely available online e.g. from NCBI. $\endgroup$ – tyersome Oct 17 at 17:53
  • $\begingroup$ @tyersome primitive strand! 🤦‍♂ I mean original DNA strand. Thanks a lot for mentioning that. You know I should translate everything and this is really difficult for me. $\endgroup$ – Sajad Safarian Oct 17 at 19:03
  • $\begingroup$ @tyersome I watched Khan Academy videos about replication but it didn't meet my needs. Please help. $\endgroup$ – Sajad Safarian Oct 17 at 19:12

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