I am reading a journal paper about the relationship between NCAM2 and autism. I have come across the following statement in the paper:
Based on analysis utilizing the UCSC Genome Browser (hg18, build 36), there are a total of 19 genes deleted (Table I). The proximal deletion breakpoint falls within the NCAM2 gene, deleting 17 out of 18 exons, and the distal deletion involves 16 out of 17 exons of the GRIK1 gene.
I am not sure what is meant by a 'proximal deletion breakpoint'. I have tried searching for the definition online but I have not found anything useful. Any insights are appreciated.