Have there been any experimentally-verified systems of microRNAs targeting a gene set (e.g., in cancer, perhaps)?
$\begingroup$
$\endgroup$
Add a comment
|
1 Answer
$\begingroup$
$\endgroup$
Yes. Below is a link to a review of ncRNA (non-coding RNAs) and their role in disease. There are many examples in this review in all sorts of diseases, one of which is miR-200, which is thought to play a role in some cancers.
There are also some tables in the paper that list the miRNA and the disease they are linked to. They also have a reference for each one, so you could read more about that particular miRNA and its function, including the gene it regulates.
http://www.nature.com/nrg/journal/v12/n12/full/nrg3074.html
Im not sure if that article is open to the public or not. If you cant access it you could always check out the wikipedia entry for miR-200
