I'm asking this as a layperson without much knowledge in biology, so please correct me if my understanding is wrong.
Recently DeepMind's AlphaFold managed to predict protein structure from acid amino sequence with stunning accuracy. We are being told that this could "pave ways toward advances in drug discovery."
But I fail to see how it can happen. From my understanding the combination of protein structure is infinite, and if we tweak a protein structure that works good to fight against a virus, it will either work better or worse, but the key point is we don't know until we try. So essentially this is still a hit-and-miss thing, depending purely on dumb luck.
So how can the fast, accurate prediction of protein folding help in drug discovery?