Transferrin Saturation (TS) is a common laboratory test and its values can be used to diagnose a variety of medical conditions.
In healthy humans, and I assume it is the same for other species, TS is typically found to be around 30%. Values above 50% are considered very suspect of hemochromatosis. This means that in healthy humans, at least 50% of the transferrin found in plasma is useless, at least with regards to iron metabolism. In particular, the bioavailability of plasmatic iron does not seem to depend on TS.
My question is therefore: what is the reason for the low TS value typically found in humans? Has it any known evolutionary advantage? I have not been able to find answers in the literature. Thank you very much for your help.


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