Does V(D)J recombination only happen in B and T cell development? Can it happen in other types of cells?
If V(D)J recombination only happens in B and T cell development, why other types of cells cannot have V(D)J recombination?
V(D)J recombination rearranges the DNA sequences of maturing B and T cells that encode proteins for recognizing antigens, so that different B and T cells may recognize different antigens for initiating further immune response.
Recombination activating gene 1 (RAG1) and RAG2 proteins are essential for rearranging the DNA sequences in V(D)J recombination. RAG recognize specific DNA sequences, called recombination signal sequences (RSSs), that are adjacent to the variable regions of the genes that encode proteins for antigen recognization.
V(D)J recombination occasionally happens in natural killer (NK) and dendritic cells [1, 2].
So the answer to my question is that V(D)J recombination is not restricted to B and T cell development.
I would like to thank @swbarnes2 for pointing out the importance of RAG1 in V(D)J recombination. Also thank @MattDMo for introducing me to the community guidelines.
This question is not my homework. I am just curious why V(D)J recombination seems to be only discussed in the context of B and T cell development.
 Kuo TC, Schlissel MS. Mechanisms controlling expression of the RAG locus during lymphocyte development. Curr Opin Immunol. 2009;21: 173–178.
 Borghesi L, Hsu L-Y, Miller JP, Anderson M, Herzenberg L, Herzenberg L, et al. B lineage-specific regulation of V(D)J recombinase activity is established in common lymphoid progenitors. J Exp Med. 2004;199: 491–502.
Added some highlights to my edit 1.