A scientist from Harvard, David Sinclair, has a few videos, a book and some papers on the topic of ageing. Particularly, I've seen this video a couple of times where he explains their discoveries on the biochemistry of ageing.
- The first part of the talk (min 6 to 20 or so) is about why do we age,
- the rest to how to reset ageing.
As to why do we age, he postulates it's because of broken chromosome(s) disrupting the spatial structure of DNA/other chromosomes, and consequently the expression of genes.
[The chromosome-lysis could be due to UV rays or ROS, or any other cause.]
He also claims methylation has to do with ageing and that it is a measure of ageing (18:00). But DNA methylation is a mutation and is changing the DNA sequence more than the epigenome.
My question here is: Is chromosome-lysis actually proven to be the main factor why we/mices age? How does methylation fits here?