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Flip-flopping of lipids (and in proteins it is impossible) in plasma membrane is rare due to high energy barrier (video ref). However, it is an important mechanism since it allows asymmetric distribution of lipids in cell membrane.

Question: If a specific lipid is flipped E.g. phosphatidylinositol from cytoplasm side to extra-cellular side (E.g. by flippase), what mechanism can the cell do to ensure it will stay towards the extra-cellular fluid side but not flip-flop AGAIN (i.e. establish the asymmetry & enable its function)?

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