Do the 46 human chromosomes form a single unbroken DNA helix? Or is it rather that a human's genome consists of 46 disconnected helices?
If it is the former, does the common numbering scheme for the chromosomes have any correlation to their actual ordering in the one large strand?
If is the latter, is there a convention on how the chromosomes are ordered in genomic datasets? Also, is there a clear understanding of how sister chromosomes "find" each other in Meiosis I?
Generally, during periods when Mitosis/Meiosis are not occurring, what's a good physical picture for how the chromosomes are physically arranged (e.g. a bowl of 46 spaghetti noodles, or maybe the sister chromosomes always stay close together, etc)