Questions tagged [allele]

Alleles are different forms of many possible alternative forms of the same gene. The different eye colors are for example different alleles of the genes that make the eye color.

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Is there a practical upper limit to ploidy?

In my AP Biology class, we were discussing polyploidy, specifically, its deleterious nature in mammals and its prevalence in plants. We also learned that commercial crops, especially fruit, are often ...
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When to decide that two similar sequences are different genes or not?

Working on RNA-Seq data directed me to ask this question. In RNA-Seq jobs, after de novo assembly we have lots of transcripts with different rates of similarity (0 to almost 100 percent) that we ...
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What is allele-specific binding?

So far all I have found is this: https://www.biostars.org/p/132527/ My guess is that some alleles, for whatever reason, bind to things like transcription factors 'moreso' (for want of better word - ...
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What is the best test for SNV clustering?

I am looking for a method to cluster single nucleotide polymorphisms based on clinicopathologic data (mainly receptor immunoistochemistry). So far, I've came up with only two that handle dummy ...
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54 views

Does the law of independent assortment apply to homologous chromosomes or alleles, or both?

My textbook is giving me two definitions 1st def: "random orientation of homologous chromosomes at the metaphase plate in meiosis 1." 2nd def: "alleles for one gene separate into gametes ...
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Is bi-allelic gene expression random?

Supposing we have the genotypes “Aa”, “AA”, and “aa”... which are not mono-allelic (not imprinted and not X-inactivated). Does the dominance of the “A” allele over “a” allele affect which gene is ...
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508 views

Interpreting Allele frequency and allele count

In the following vcf file, the AF allele frequency of ALT allele is 1.0. Does it mean that it is not a true SNP of interest? Does it also mean that ALT allele always occurs and REF allele never ...
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59 views

“Genotype structure”?

What does a geneticist mean when they write "genotype structure", e.g. the sentence "...represents continuous allele frequencies for both tumor and normal samples, while leveraging the expected ...
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What is minor allele frequency, global allele frequency and global minor allele frequency?

Please explain minor allele frequency, global allele frequency and global minor allele frequency in simple words.
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Simple Autosomal Recessive question by a novice genetics student

How do you figure the percentage of offspring that will be a carrier of an Autosomal Recessive gene when the FATHER is the recessive carrier and the MOTHER is not affected (normal, no recessive)? ...
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611 views

How does selection affect allele frequency?

Question People who are carriers for Blooms Syndrome have developed a selective advantage. How would this affect the allele frequency of the disease allele? My thoughts Natural selection will ...
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41 views

is it possible for a son to inherit an allele on a Y chromosome?

Obviously, the only way for one to be male is to inherit the Y chromosome, but are there alleles on the y chromosomes? Or is it just automatically the recessive trait without an allele.